Rickets: Types, Causes, Diagnosis, Symptoms and Treatment

Rickets: Types, Causes, Diagnosis, Symptoms and Treatment- Rickets is a bone disorder caused by a deficiency of vitamin D, calcium, or phosphate. Rickets leads to softening and weakening of the bones and is seen most commonly in children 6-24 months of age. Vitamin D promotes the absorption of calcium and phosphorus from the gastrointestinal tract. A deficiency of vitamin D makes it difficult to maintain proper calcium and phosphorus levels in bones, which can cause rickets.

Types of rickets

There are various types of rickets are as follows

 Nutritional Rickets:

 Due to dietary deficiency of calcium, Vitamin D. You can correct it with including good sources of Calcium, Vitamin D, phosphorus.

Sources of Vit D include sunlight, fatty fish, milk, mushrooms

Sources of Calcium include Milk and products, gingelly seeds, Ragi, tofu, soy milk, figs, rajgeera (Amaranth seeds), Almonds, figs etc.

Sources of phosphorus include milk and products, ricebran, pulses and legumes, rajgeera (amaranth seeds), pumpkin seeds, colocasia leaves, gingelly seeds, carrot , bajra, maize etc.

 Hypophosphatemic Rickets:

As the name suggests this particular form of Rickets is caused due to low levels of phosphate. Bones become painfully soft and pliable. It is caused by a genetic dominant X-linked defect in the ability for the kidneys to control the amount of phosphate excreted in urine. It is not caused by Vit D Deficiency. Children suffering from this type of Ricket show obvious symptoms by the time they are 1 year of age. Treatment is generally through nutritional supplementation of phosphate and active form of Vit D.

Renal Rickets:

Caused by a number of kidney disorders. Persons suffering from kidney disorder have decreased ability to regulate amounts of electrolytes lost in urine which includes electrolytes like calcium and phosphate. Thus, these individuals develop symptoms similar to those of rickets

Risk factors of rickets 

Factors that can increase a child’s risk of rickets include:

Dark skin: Dark skin doesn’t react as strongly to sunshine as does lighter skin, so it produces less vitamin D.

Mother’s vitamin D deficiency during pregnancy: A baby born to a mother with severe vitamin D deficiency can be born with signs of rickets or develop them within a few months after birth.

Northern latitudes: Children who live in geographical locations where there is less sunshine are at higher risk of rickets.

Premature birth: Babies born before their due dates are more likely to develop rickets.

Medications: Certain types of anti-seizure medications and antiretroviral medications, used to treat HIV infections, appear to interfere with the body’s ability to use vitamin D.

Exclusive breast-feeding: Breast milk doesn’t contain enough vitamin D to prevent rickets. Babies who are exclusively breast-fed should receive vitamin D drops.

Causes of rickets

Your body needs vitamin D to absorb calcium and phosphorus from food. Rickets can occur if your child’s body doesn’t get enough vitamin D or if his or her body has problems using vitamin D properly. Occasionally, not getting enough calcium or lack of calcium and vitamin D can cause rickets.

Lack of vitamin D

Children who don’t get enough vitamin D from these two sources can develop a deficiency:

Your skin produces vitamin D when it’s exposed to sunlight. But children in developed countries tend to spend less time outdoors. They’re also more likely to use sunscreen, which blocks the rays that trigger the skin’s production of vitamin D.

Fish oils, fatty fish and egg yolks contain vitamin D. Vitamin D also has been added to some foods, such as milk, cereal and some fruit juices.

Signs and symptoms of rickets

• Baby is ‘floppy.’
• Bone pain.
• Bone tenderness.
• Bones break easily.
• Costochondral swelling – prominent knobs on the bone between the ribs and the breast plate.
• Harrison’s groove – a horizontal line visible on the chest, where the diaphragm attaches to the ribs.
• Low calcium blood levels (hypcalcemia).
• Older children may have knock knees (genu valgum).
• Soft skull (craniotabes).
• Low physical growth (height and weight) may be affected.
• There may be spinal, pelvic, or cranial deformities.
• Toddlers may have bowed legs (genu varum).
• Uncontrolled muscle spasms, which may affect the entire body (tetany).
• Widening wrists.

Symptoms vary in severity and may be intermittent.

Complications  of rickets

Left untreated, rickets can lead to:

• Failure to grow
• Abnormally curved spine
• Skeletal deformities
• Dental defects

Seizures

Diagnosis and test for rickets

The diagnosis of rickets is achieved in the following ways:

Blood tests :measures levels of calcium and phosphorus. Levels of alkaline phosphatase may also be high.

Arterial blood gases: checks how acidic the blood is.

X-rays: these may reveal calcium loss in bones, or alterations in the structure or shape of the bones.

Bone biopsy: this can confirm rickets (rarely used).

Physical symptoms of rickets, such as bowed legs or a soft skull, will also be checked; however, these are not reliable enough to use on their own.

Treatment and medications of rickets

Simply, treatment focuses on increasing the patient’s intake of calcium, phosphates, and vitamin D. This may involve exposure to sunlight, consuming fish oils, and ergocalciferol or cholecalficerol (forms of Vitamin D).

Exposure to ultraviolet B light and consuming calcium and phosphorus is usually enough to reverse or prevent rickets.

If rickets is caused by bad diet, the patient should be given daily calcium and vitamin D supplements, an annual vitamin D injection, as well as being encouraged to eat vitamin D rich foods.

Treating genetic rickets – the patient will be prescribed phosphorus medications and active vitamin D hormones.

Other medical conditions – if rickets has an underlying medical cause, such as kidney disease, that disease needs to be treated and controlled.

What is the prognosis for rickets?

Outcomes for children with nutritional rickets are excellent, especially if diagnosed early. Appropriate supplementation with calcium and vitamin D will lead to healing of the bony defects within days to months. Severe bowing, seen in longer-standing cases of rickets, may also resolve over a number years without requiring surgical intervention. In patients with very advanced disease, however, the bony changes may be permanent.

Prevention of rickets

Estimating the exact vitamin D needs of each human is very difficult, because it is hard to measure how much of the vitamin is synthesized in the skin via sunlight.

In countries that are not near the tropics and sunlight intensity is lower, it is important to provide a supplementary intake of vitamin D to prevent rickets.

This may involve:

Enriching milk, baby foods, and some other food products

The administration of a daily vitamin D supplement

Massive doses of vitamin D when it is impossible for socioeconomic reasons to provide a vitamin supplement

In areas with a lot of sunlight, the best way to prevent rickets is to expose the child to the sun.

While exposure to sunlight is a good source of vitamin D, it is important not to overdo it – excess sunlight exposure can lead to sunburn and eventually skin cancer.